About Me

2 years to conceive a baby is the last thing I thought could happen to us...

Let me tell you a bit about myself. I'm 25 and my husband is 27. We have been together since Oct 13, 2000 - I was 16 & he was 18. We've got married Dec 24, 2006. We started trying to conceive in February 2007 with no success.

In September 2007 we were referred to our current doctor (RE) and she specializes in Gynecologic Reproductive Endocrinology & Infertility MSc, MD, FRCSC at fertility clinic in Toronto. Me and my husband did many test which all came back with great results. We were tested through Sonohysterogram, Laporoscopy, Hysteroscopy, Hysterosalpingogram (HSG), Semen DNA Fragmentation to name a few...

We did 3 IUI's; Then we decided to start doing IVF to increase our chances. Unfortunately, we found out that I have unexplained poor response to medications. We spent over $36,000 out of the pocket just in 2007 & 2008 for all our procedures. We had 4 failed IVF attempts, some canceled after weeks of expensive injections. Every cycle was a heartbreak and the pain never goes away.

Our diagnosis is UNEXPLAINED INFERTILITY
Unexplained poor responder
Unexplained elevated prolactin
  • Natural - Feb.’07-Oct. ’07;
  • IUI#1 - Nov '07- Clomid 50mg (cd5-9); HCG; Progesterone 400g;
  • IUI#2 - Jan '08- Clomid 50mg (cd5-9); HCG; Progesterone 400mg;
  • IVF#1 - Long Agonist Protocol; Feb '08 - BCP; Mar '08 - Suprefact / Puregon 175IU; Canceled after 9 weeks of injections due to 3.2cm cyst on the right ovary
  • IVF#2 - Long Agonist Protocol; April '08 BCP; May '08 - Puregon 200 IU/Orgalutran 250 mg; ER May 14 - ET May 17; 5 eggs-3 mature-2 fertilized; Day 3 transfer; transferred two 8-cell & 7-cell grade 1 embies; Progesterone 600mg;
  • Natural - June ’08; Aspirin 81mg/Pre-Seed;
  • IVF#3 - Short Antagonist Protocol; July '08 - Canceled after 10 days of injections due to elevated prolactin 36.6 & poor response; only 8 follicles and not developing
  • IVF#4 - Short Antagonist Protocol; Aug/Sept' 08 -Gonal-f (225iu)/Menopur (150iu); Cetrotide (250mg);Ovidrel 10,000 IU; Progesterone in oil injections (50mg), Aspirin (81mg) Cancelled after 12 days of injections (less than 7 follicles); Later converted to IUI#3
  • IVF#5 - Estrogen Priming with MicroFlare Protocol; Oct '08 - Start Estrace Oct5 (7DPO); Stop next CD2 after AF (Oct11) start stim with Gonal-F (450iu) & microdose of Lupron/Suprefact (0.05iu); Took Aspirin 81 mg; Almost canceled due to poor response after 13 days of injections (only 6 follicles developing) + ovarian cysts; ER on cycle day 21 (!!!) after 18 days of stims; Got 10 eggs; 7 mature; 5 fertilized with ICSI; Day 5 transfer of 2 blastocysts (2AB both); one was hatching; None to freeze, all arrested; Crinone 8% & Estrace 6mg after ET
  • Greater than 50% of patients achieve pregnancy on their first IVF cycle.
  • Close to 50% of patients who had a second cycle also achieved pregnancy.
  • Finally, 40% of patients who did a third cycle achieved a clinical pregnancy.

Statistically, most people have become pregnant by their third cycle.

Thursday, September 25, 2008

IVF#5 - !!!!!

Had my review today and I'm on to:

Estrogen Priming & MicroFlare Protocol - Supposed to work for unexplained poor responders.

Daily b/w from now on to see when my LH surge/ovulation happens. Today is my cycle day 14 so they want to see if I ovulated already or just going to. My RE wanted to do Flare and I convinced her to do Estrogen as well...so basically I start Estrace vaginal pills as of day 21 to AF. Then just start stimulation with Gonal-F 450iu Shocked which is a max dose of any stimulation drug (around Oct 10) with a very-very small dose of Lupron/Superfact at the same time. Then Crinone for progesterone support.

ER should be around Oct 23, though they said that estrogen priming sometimes makes it longer to stimulate like 14-18 days of stims before ER.

Flare Protocol is one of the most potent IVF protocols available. It has helped many women with poor ovarian reserves to conceive, and in our opinion, is the last resort before donor egg IVF. The protocol takes advantage of a special property of Lupron. When used in tiny amounts, Lupron stimulates the release of natural FSH from the pituitary for several days before exerting its suppressive effect. During this 'flare' period, the ovaries are stimulated by natural FSH. The subsequent addition of high doses of FSH from medications gives the ovaries maximum stimulation.

Estrogen Priming of FSH receptors has been reported to slow premature follicular development and to promote granulosa cell FSH receptor induction. Estrogen support of the endometrium with vaginal suppositories was used to maintain the endometrium and to prevent withdrawal bleeding until an estrogen-producing follicle has emerged. This protocol over the past four years has given several insights into the treatment of poor prognosis patients. Basically it helps improve egg quality and help with leading follicles becoming too big before the rest of small follicles catch up.

I'm not even excited though...

Oh, and this time we are going to do day 5 transfer regardless of how many embryos I have because we want to see if maybe they stop developing after day 3, so maybe we will know that it's not implantation issue but embryo issue...
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