About Me

2 years to conceive a baby is the last thing I thought could happen to us...

Let me tell you a bit about myself. I'm 25 and my husband is 27. We have been together since Oct 13, 2000 - I was 16 & he was 18. We've got married Dec 24, 2006. We started trying to conceive in February 2007 with no success.

In September 2007 we were referred to our current doctor (RE) and she specializes in Gynecologic Reproductive Endocrinology & Infertility MSc, MD, FRCSC at fertility clinic in Toronto. Me and my husband did many test which all came back with great results. We were tested through Sonohysterogram, Laporoscopy, Hysteroscopy, Hysterosalpingogram (HSG), Semen DNA Fragmentation to name a few...

We did 3 IUI's; Then we decided to start doing IVF to increase our chances. Unfortunately, we found out that I have unexplained poor response to medications. We spent over $36,000 out of the pocket just in 2007 & 2008 for all our procedures. We had 4 failed IVF attempts, some canceled after weeks of expensive injections. Every cycle was a heartbreak and the pain never goes away.

Our diagnosis is UNEXPLAINED INFERTILITY
Unexplained poor responder
Unexplained elevated prolactin
  • Natural - Feb.’07-Oct. ’07;
  • IUI#1 - Nov '07- Clomid 50mg (cd5-9); HCG; Progesterone 400g;
  • IUI#2 - Jan '08- Clomid 50mg (cd5-9); HCG; Progesterone 400mg;
  • IVF#1 - Long Agonist Protocol; Feb '08 - BCP; Mar '08 - Suprefact / Puregon 175IU; Canceled after 9 weeks of injections due to 3.2cm cyst on the right ovary
  • IVF#2 - Long Agonist Protocol; April '08 BCP; May '08 - Puregon 200 IU/Orgalutran 250 mg; ER May 14 - ET May 17; 5 eggs-3 mature-2 fertilized; Day 3 transfer; transferred two 8-cell & 7-cell grade 1 embies; Progesterone 600mg;
  • Natural - June ’08; Aspirin 81mg/Pre-Seed;
  • IVF#3 - Short Antagonist Protocol; July '08 - Canceled after 10 days of injections due to elevated prolactin 36.6 & poor response; only 8 follicles and not developing
  • IVF#4 - Short Antagonist Protocol; Aug/Sept' 08 -Gonal-f (225iu)/Menopur (150iu); Cetrotide (250mg);Ovidrel 10,000 IU; Progesterone in oil injections (50mg), Aspirin (81mg) Cancelled after 12 days of injections (less than 7 follicles); Later converted to IUI#3
  • IVF#5 - Estrogen Priming with MicroFlare Protocol; Oct '08 - Start Estrace Oct5 (7DPO); Stop next CD2 after AF (Oct11) start stim with Gonal-F (450iu) & microdose of Lupron/Suprefact (0.05iu); Took Aspirin 81 mg; Almost canceled due to poor response after 13 days of injections (only 6 follicles developing) + ovarian cysts; ER on cycle day 21 (!!!) after 18 days of stims; Got 10 eggs; 7 mature; 5 fertilized with ICSI; Day 5 transfer of 2 blastocysts (2AB both); one was hatching; None to freeze, all arrested; Crinone 8% & Estrace 6mg after ET
  • Greater than 50% of patients achieve pregnancy on their first IVF cycle.
  • Close to 50% of patients who had a second cycle also achieved pregnancy.
  • Finally, 40% of patients who did a third cycle achieved a clinical pregnancy.

Statistically, most people have become pregnant by their third cycle.

Wednesday, October 8, 2008

BRCA1 - My genes are holding me down!!!!!

....I have not posted for a while. I am just a bit depressed.

I am depressed because I've been having issue with my IVF future that stirred up my other issues and it's a big mess that I don't want to think about and it makes me emotional...

Well, my mom passed away at the age of 50 in 2004. I just turned 20 and quit my job and second year university to stay by her bedside for 5 months of palliative care. She always struggled with cancer and every woman in my family died before reaching 50. My mom had her breast removed at 31 to save her live and the battle never ended ever since. I didn't know about it because my mom was strong and shielded me and my sister from it. Before she passed away, doctors and oncologists were shocked by her aggressive breast cancer, ovarian cancer, esophagus cancer that were all non related...They tested her positive for BRCA1 gene...

BRCA1 is a breast cancer susceptibility gene. People who carry a mutation (abnormality) in this gene are at an increased risk of breast or ovarian cancer. The normal gene plays a role in repairing breaks in DNA. However, when the gene is mutated it is thought that this repair function may become disabled thus leading to more DNA replication errors and cancerous growth.A woman's lifetime chance of developing breast and/or ovarian cancer is greatly increased if she inherits an altered BRCA1 or BRCA2 gene. Women with an inherited alteration in one of these genes have an increased risk of developing these cancers at a young age..

People who carry the gene have an average 81% lifetime risk for breast cancer and 60% chance of ovarian cancer...

They tested me and my sister and we both have it...

Back to the point...

My case was taken to the medical board and they were very concerned that I am even undergoing any treatments because hormones are my enemy. I am under no circumstances allowed to have any fertility treatments. My oncologist and cancer clinic that I go to believe that it is very bad that I took all those hormones and that I should have never been allowed to take them in the first place. They said they understand that I want a baby but I most likely accelerated my chances of cancer. They said it is ok to complete this IVF cycle , maybe one more cycle after that...... but no more...NEVER because it jeopardize my chanced for future survival...

I need to get pregnant because I have already been advised by oncologist to face the fact that in order to survive this fate I will most likely have to undergo preventative surgery to reduce the risk of developing breast cancer by removing one or both breasts before the disease develops. Also called prophylactic mastectomy. As well as surgical removal of the fallopian tubes, ovaries & uterus. Preferably by the age of 35-40.

This IVF has to work or I'm out on my own in search for miracles..

I don't have time to wait for miracles.....

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I just want you to know that my post does not call for pity. I just merely wanted to share why I feel so negative...

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