About Me

2 years to conceive a baby is the last thing I thought could happen to us...

Let me tell you a bit about myself. I'm 25 and my husband is 27. We have been together since Oct 13, 2000 - I was 16 & he was 18. We've got married Dec 24, 2006. We started trying to conceive in February 2007 with no success.

In September 2007 we were referred to our current doctor (RE) and she specializes in Gynecologic Reproductive Endocrinology & Infertility MSc, MD, FRCSC at fertility clinic in Toronto. Me and my husband did many test which all came back with great results. We were tested through Sonohysterogram, Laporoscopy, Hysteroscopy, Hysterosalpingogram (HSG), Semen DNA Fragmentation to name a few...

We did 3 IUI's; Then we decided to start doing IVF to increase our chances. Unfortunately, we found out that I have unexplained poor response to medications. We spent over $36,000 out of the pocket just in 2007 & 2008 for all our procedures. We had 4 failed IVF attempts, some canceled after weeks of expensive injections. Every cycle was a heartbreak and the pain never goes away.

Our diagnosis is UNEXPLAINED INFERTILITY
Unexplained poor responder
Unexplained elevated prolactin
  • Natural - Feb.’07-Oct. ’07;
  • IUI#1 - Nov '07- Clomid 50mg (cd5-9); HCG; Progesterone 400g;
  • IUI#2 - Jan '08- Clomid 50mg (cd5-9); HCG; Progesterone 400mg;
  • IVF#1 - Long Agonist Protocol; Feb '08 - BCP; Mar '08 - Suprefact / Puregon 175IU; Canceled after 9 weeks of injections due to 3.2cm cyst on the right ovary
  • IVF#2 - Long Agonist Protocol; April '08 BCP; May '08 - Puregon 200 IU/Orgalutran 250 mg; ER May 14 - ET May 17; 5 eggs-3 mature-2 fertilized; Day 3 transfer; transferred two 8-cell & 7-cell grade 1 embies; Progesterone 600mg;
  • Natural - June ’08; Aspirin 81mg/Pre-Seed;
  • IVF#3 - Short Antagonist Protocol; July '08 - Canceled after 10 days of injections due to elevated prolactin 36.6 & poor response; only 8 follicles and not developing
  • IVF#4 - Short Antagonist Protocol; Aug/Sept' 08 -Gonal-f (225iu)/Menopur (150iu); Cetrotide (250mg);Ovidrel 10,000 IU; Progesterone in oil injections (50mg), Aspirin (81mg) Cancelled after 12 days of injections (less than 7 follicles); Later converted to IUI#3
  • IVF#5 - Estrogen Priming with MicroFlare Protocol; Oct '08 - Start Estrace Oct5 (7DPO); Stop next CD2 after AF (Oct11) start stim with Gonal-F (450iu) & microdose of Lupron/Suprefact (0.05iu); Took Aspirin 81 mg; Almost canceled due to poor response after 13 days of injections (only 6 follicles developing) + ovarian cysts; ER on cycle day 21 (!!!) after 18 days of stims; Got 10 eggs; 7 mature; 5 fertilized with ICSI; Day 5 transfer of 2 blastocysts (2AB both); one was hatching; None to freeze, all arrested; Crinone 8% & Estrace 6mg after ET
  • Greater than 50% of patients achieve pregnancy on their first IVF cycle.
  • Close to 50% of patients who had a second cycle also achieved pregnancy.
  • Finally, 40% of patients who did a third cycle achieved a clinical pregnancy.

Statistically, most people have become pregnant by their third cycle.

Friday, February 27, 2009

Poor Egg Quality...Really???

I always hear stories of doctors telling their patients after a failed cycle that their egg quality is not good. Usually a patient entrusts their self into the hands of a doctor and leaves the office with a prognosis of future donor eggs. I don't like when that happens. I truly believe that some doctors take advantage of patients that do not do their own research and believe everything they say.

First, let me ask you this - Did your RE explain exactly how your eggs are bad quality? What exactly is wrong with them? You should be able to find out that information.

For example an egg is comprised of a shell (zona pellucida or just“zona”) and the cytoplasm (ooplasm) which, after fertilization, will grow and develop into the embryo. Every lab inspects eggs upon retrieval and they usually have to make notes of their findings. For example, a good egg would have a zona that is perfectly round, that does not have any distortions/deformities and is most often tightly surrounds the actual egg inside. So, if you have a poor egg quality, your RE should be able to to tell you, whether your eggs have a zona that is way too thick or deformed, which can prevent normal fertilization, embryo hatching and thus implantation. Also, you may have a cytoplasm that is way too big to properly surround and "snug" the egg, thus the actual egg within could potentially become damages from “floating” around. There are many more standards by which your eggs are evaluated like fragmentation, color, etc. Poor eggs sometimes will have dark color and look “degenerative” under the microscope.

You must also know that currently, there is not one single test out there that can conclusively determine egg quality. There is no one perfect test for egg quality. Therefore most labs, and RE’s base their assumptions of your eggs ability to become fertilized and produce normal embryos. Therefore I also believe that just one or two failed IVF’s is not the end of the road, since in every cycle your eggs will differ depending on which particular eggs will be produced during that particular cycle. Each cycle is different with different eggs playing the game of baby making. Know that a normal looking egg may possess underlying genetic problems where an egg that appears “poor” may be chromosomally normal and go on to becoming a healthy baby.

So please, don't take one doctor's opinion and give up on having your own babies. Like I said before, having a PhD does not mean they are not human and can predict your fate...You are strong and can’t try again, go for second opinion, third, forth if you need to. Also there are some clinics that specialize in giving women that other doctors gave up on, their own babies. I've heard amazing things about Cornell Center for Reproductive Medicine and Infertility in New York; Colorado Center for Reproductive Medicine; SHER Institutes For Reproductive Medicine.

Do your research and stay strong, don't give up. This road is tough but your are a fighter and you will hold your baby in your arms someday.

3 comments:

Victoria said...

Good information and a good way to inform others. We often put our trust in our doctors words and hands. Your journey shows your determination to succeed. Some people would have given up after two or three times. Congrats!

Anonymous said...

Thank you Victoria. I try to encourage people to seek second opinion and not to give up. There are so many doctors out there that can make it happen. We all just have to find the right one.

Mysterious UnFruitfulnesses

Nadine said...

I have been told i have poor egg quality, based on 10 eggs and only 1 normal embryo at day 3 (but i have endometriosis and it makes sense). All that said, i have been working on improving egg quality for 8 months and I am doing a new protocol so I am very hopeful!